AKT1 and neoplasm: 29. Another study indicated a consistence between RhoA expression and the results of a functional study on miR‐126. In particular, miR‐126 downregulated Rho/Rac guanine nucleotide exchange factor 2 and elevated Rho GTPase‐activating protein 5, followed by inactivation of Rho GTPase and the Rho GTPase signaling pathway, to exert its tumor suppressor role in colon cancer cells 43.