The causes of DFO‐mediated iron depletion–associated cell cycle perturbations and apoptosis observed in multiple cancer cell types involve mainly dNTP deficiency, resulting from inactivation of RR in DFO‐treated cell lines,8, 10 and down‐regulation of cyclin D1 because of the mechanisms that are not yet unequivocally established.8, 12, 13 Cyclin D1 has been postulated a therapeutic target in MCL because of its pro‐proliferation and anti‐apoptotic function in MCL43; therefore, iron chelation targeting cyclin D1 could represent a promising alternative treatment strategy. Here, CCND1 is linked to cancer.