RB1 and cancer: It has been shown that in MCL cell lines, iron chelator deferasirox down‐regulates cyclin D1 which in turn leads to inhibition of Rb phosphorylation and increase of the E2F/Rb complex levels ultimately leading to G1/S arrest.5 The mechanism by which iron may affect cyclin D1 in cancer cells has been suggested by Nurtjahja‐Tjendraputra et al12 in a study that examined the ability of iron chelators to inhibit cell proliferation and induce apoptosis.