CDK5 and Alzheimer disease: Bakhtiari et al. (2017) ▶ reported the role of flavonoids (one of the ZM essential oil compounds) in inhibiting specific enzymes involved in tau protein phosphorylation, such as β-secretase, glycogen synthase and kinase-dependent cyclin 5, all of which could contribute to beneficial effects of flavonoids on AD (Bakhtiari et al., 2017 ▶).