Geleophysic dysplasia (GPHYSD1, MIM231050; GPHYSD2, MIM614185; GPHYSD3, MIM617809) presents with short stature, small hands and feet, cardiac valvular disease, hepatomegaly, joint contractures, and thickened skin [1,2]. Here, LTBP3 is linked to geleophysic dysplasia.