Previous studies showed that PAK‐1 mediated the growth of prostate PC‐3 cell tumor xenografts in athymic nude mice as well as the transforming growth factor‐β (TGFβ)‐induced prostate cancer cell epithelial‐mesenchymal transition (EMT).11 These studies suggested that PAK‐1 plays a major role in prostate cancer progression and is a potential target for prostate cancer therapy. The gene discussed is TGFB1; the disease is Familial prostate cancer.