PAK1 and Familial prostate cancer: DU‐145 cells were chosen as these cells were shown to be resistant to the effect of IPA‐3 in our previous studies and because they have a high level of expression of PAK‐1, compared to other prostate cancer cells.18 MCF‐7 cells were chosen based on the fact that they had the highest level of PAK‐1 expression among the cells described in Figure 1.