However, on the other side of the spectrum, a study targeting Alzheimer’s disease via rat central nervous system cell line models found that the overexpression of PDK1 (along with lactate dehydrogenase A) conferred a resistance to Ameloid β and other toxins, thereby mitigating some of the mechanisms underlying Alzheimer’s disease progression [49]. This evidence concerns the gene PDK1 and early-onset autosomal dominant Alzheimer disease.