SNHG6 and colorectal carcinoma: We also employed flow cytometry to show that 5-FU induced CRC cell apoptosis and that SNHG6 knockdown enhanced drug-induced apoptosis in RKO and HT29 cells (Fig. 1g, h, Additional file 1: Figure S1d) but overexpression decreased it in RKO and HCT116 cells (Fig. 1i, j, Additional file 1: Figure S1d).