IL6ST and diffuse large B-cell lymphoma: A third adaptation of ABC‐DLBCL cells attesting to their dependence on constitutive STAT3 activation is the mutational inactivation of SOCS1. SOCS1 negatively regulates STAT3 phosphorylation downstream of gp130; indeed, the only ABC‐DLBCL cell line in our panel that harbors an inactivating SOCS1 mutation (Juskevicius et al, 2018) was independent of IL‐6 with respect to its constitutive STAT3 activation.