A third adaptation of ABC‐DLBCL cells attesting to their dependence on constitutive STAT3 activation is the mutational inactivation of SOCS1. SOCS1 negatively regulates STAT3 phosphorylation downstream of gp130; indeed, the only ABC‐DLBCL cell line in our panel that harbors an inactivating SOCS1 mutation (Juskevicius et al, 2018) was independent of IL‐6 with respect to its constitutive STAT3 activation. Here, IL6ST is linked to aneurysmal bone cyst.