To address in a genetically engineered model of MYC‐driven lymphoma whether IL‐6 signaling contributes to the lymphoma burden, we crossed C57BL/6 mice expressing Cre recombinase under the activation‐induced cytidine deaminase promoter (AID‐Cre) with mice harboring floxed Il6ra alleles, which resulted in a composite strain lacking IL‐6 signaling specifically in the germinal center (GC) B‐cell compartment after immunization with sheep red blood cells. This evidence concerns the gene AICDA and lymphoma.