There are three different AKT isoforms, AKT1, AKT2 and AKT3.27 AKT is an important signalling pathway in regulating several cellular functions including nutrient metabolism, cell growth, apoptosis and survival.28 AKT3 has been reported to be involved in cancer progression and plays important role in the regulations of various human cancers associated with miRNAs to modulate human cancers.29, 30, 31. The gene discussed is AKT1; the disease is cancer.