APOE and Alzheimer disease: To diagnose inflammation and AD, a control (non-Tg mouse), an ApoE knockdown mouse (female, 24 weeks old) model for early inflammation, an APP/PS knockdown mouse group (40 weeks of age), and an APP/PS/ApoE KD mouse (Fig. 4A) (female, 12, 24 weeks old) model were used for severe AD.