miR-106b, miR-155, miR-200a, miR-181a, miR-124b, miR-146b, miR-34a, and miR-153 were used as markers for miRNA, and Aβ1–42 monomer, Aβ1–42 oligomer, NLRP3, UCHL1, STAT3, Tau, Visfatin, IL-13, SORL1, Clusterin, ApoE4, ApoE3, and Nogo-A were used as markers in four plasma samples from AD patients. The gene discussed is NLRP3; the disease is Alzheimer disease.