FOXA1 and Familial prostate cancer: Using our in situ Hi-C and epigenomic data, we identified two strong cancer-specific H3K27ac peaks located at ~350 and ~180 kb upstream of the transcription start site of FOXA1 that are looped to the FOXA1 promoter region in C42B prostate cancer cells (Fig. 5c); the interaction of each loop was more frequent in cancer cells compared to normal cells.