In addition, mice that lack SAP90/PSD95-associated protein 3 (Sapap3; also known as Dlgap3), a postsynaptic scaffolding protein at excitatory synapses that is highly expressed in the striatum, exhibit increased anxiety and compulsive grooming behavior combined with defects in corticostriatal synapses80. The gene discussed is DLGAP3; the disease is Anxiety.