Importantly, we observed extensive RGLS4326 uptake in both proximal tubules and collecting duct cysts in cystic kidneys of the aggressive Pkhd1/cre;Pkd2F/F (Pkd2-KO) mouse model of ADPKD following SC administration, likely linked to the severely disrupted kidney architecture in this mouse model (Fig. 4e). Here, PKHD1 is linked to autosomal dominant polycystic kidney disease.