PKHD1 and Renal cyst: Importantly, we observed extensive RGLS4326 uptake in both proximal tubules and collecting duct cysts in cystic kidneys of the aggressive Pkhd1/cre;Pkd2F/F (Pkd2-KO) mouse model of ADPKD following SC administration, likely linked to the severely disrupted kidney architecture in this mouse model (Fig. 4e).