A significant difference was demonstrated in the severity of pathologically misfolded TDP-43 inclusions, between patients with ALS-FTD and the combined non-demented clinical groups (ALS with or without cognitive impairment); however, there was no difference between the two non-demented groups: ALS with cognitive impairment and ALS with no cognitive impairment.10 An association between the cognitive profile in patients with non-demented ALS with cognitive impairment and TDP-43 has not been shown previously. Here, TARDBP is linked to Cognitive impairment.