Earlier it was shown that the STK38 gene regulates essential processes, such as centrosome duplication (Hergovich et al. 2007) and cell cycle/mitotic progression (Emoto et al. 2006) and PRKCE is involved in mitotic spindle organization (Brownlow et al. 2014; Martini et al. 2018) that supports the utility of our assay for screening new CIN genes. This evidence concerns the gene PRKCE and cervical squamous intraepithelial neoplasia.