For example, complete tumor elimination has been reported in MYC-induced osteosarcoma and lymphoma (Felsher and Bishop, 1999; Jain et al., 2002), while conversion of tumor cells to a dormant state has been reported for MYC-induced HCC and breast carcinoma, where these dormant cells can revert back to the tumor state upon oncogene reactivation (Boxer et al., 2004; Shachaf et al., 2004). The gene discussed is MYC; the disease is osteosarcoma.