Our pathway analyses of the tumor cells (T), in which the xmrk oncogene, an activated EGFR homolog (Gómez et al., 2001), was activated, and tumor-reverted cells (RFP+R), in which the oncogene was repressed, suggested some activated signaling in tumor cells, including death receptor signaling, ERK5 signaling, CXCR4 signaling, Ephrin receptor signaling and HGF signaling. The gene discussed is CXCR4; the disease is neoplasm.