PKD2 and autosomal dominant polycystic kidney disease: Nevertheless, the expression levels of TRPP2 in TLs of ADPKD2 patients were significantly lower than in TLs of control subjects as well as in those of ADPKD patients not genetically defined and ADPKD1 (Fig. 1c), suggesting that PKD2 mutation could affect the stability of TRPP2.