lncRNAs, including AFAP1-AS1 [33] and UCA1 [34], were reported to be overexpressed and act as oncogenes in the tumourigenesis of pancreatic cancer; however, these lncRNAs were also upregulated in gemcitabine-resistant AsPC-1/GR cell lines, which indicated that AFAP1-AS1 and UCA1 might be involved in the development of chemoresistance in pancreatic cancer. This evidence concerns the gene AFAP1 and familial pancreatic carcinoma.