Next, to validate whether GSTM3TV2 modulated LAT2 and OLR1 to promote chemoresistance in pancreatic cancer, we constructed the specific siRNAs targeting LAT2 and OLR1 (siLAT2 and siOLR1, respectively) to silence the expression of LAT2 and OLR1 in MIAPaCa-2/GR and Rv-AsPC-1-GSTM3TV2 cells (Additional file 6: Figure S2G, H). Here, LAT2 is linked to familial pancreatic carcinoma.