AGER and diabetic cardiomyopathy: These autopsy IHC studies, along with the synthesis of cardiac autoantibodies in uncomplicated severe DKA (36), support the hypothesis that subclinical myocarditis can be initiated by the inflammatory insults of the AGE-RAGE axis and by inflammatory cytokines in T1D/DKA, with eventual progression to diabetic cardiomyopathy in some T1D patients.