In the study by Pernthaler et al. [38] involving 58 patients with recurrent PCa with a PSA level ranged between 0.2 and 230 ng/mL, 18F-FACBC detected more accurately the presence of a local recurrence than 68Ga-PSMA, due to its favorable biodistribution. This evidence concerns the gene KLK3 and posterior cortical atrophy.