HSPA4 and cancer: The coordinated expression of HSPs was also demonstrated by Esfahani et al. in a study that systematically analyzed the proteostatic network of more than 10,000 tumor biopsies of 22 different solid tumors types, and found a consistent up-regulation of the HSP90, HSP70, Chaperonins, Prefoldins, and HSP100 gene families, describing two types of cancers according to the preferential up-regulation of the ATP-dependent chaperones [64].