The same conclusions were found by Lawicki et al. [20] and by Schrohl et al. [24], who showed that the plasma of women with mammary tumor metastasis presented higher levels of TIMP-1 than those women with primary tumors, showing both studies a relationship between plasma levels of TIMP-1 and more advanced stages of cancer and, therefore, a more unfavorable prognosis [22]. This evidence concerns the gene TIMP1 and breast cancer.