Many cancer drugs can decrease MMP8 levels along with other MMPs: The plant-based isoflavones genistein and glycitein, as well as the flavone apigenin, down-regulate MMP8 expression in vitro and inhibit leukemia cell invasion [161,162] and decrease the viability of hepatocellular carcinoma cells [163]. The gene discussed is MMP8; the disease is hepatocellular carcinoma.