However, MMP8 activity can also be harmful, as shown for pancreatic and gastric cancers [138,140], in which the interaction between MMP8 and Ephrin-B1 seems crucial, and hepatocellular carcinoma [48], where MMP8 was shown to activate the PI3K/Akt/Rac1 pathway. Here, AKT1 is linked to hepatocellular carcinoma.