Moreover, down-regulation of MUC5B has been reported to profoundly diminish proliferation, migration and invasion of human gastrointestinal cancer cells, where this reduction is mediated, at least in part, by alteration of the Wnt/β-catenin pathway and consequent reduction of β-catenin expression [87]; this is one of the key effector pathways in IPF disease [88]. The gene discussed is MUC5B; the disease is idiopathic interstitial pneumonia.