We transfected mimic miR-205-5p in p53-null A253 HNSCC cells as they have low levels of miR-205 (Figure 1B) and observed the downregulation of BRCA1 and RAD17 proteins (Figure 1C), as well as for the other selected previously validated targets E2F5 and NF-κB proteins (Figure S1A, Supplementary Materials). The gene discussed is BRCA1; the disease is head and neck squamous cell carcinoma.