When DNA is damaged, SLFN11 is recruited to the DNA damage site, co-locates with single-stranded DNA (ssDNA) binding protein replication protein A (RPA) [95], and SLFN11 then inhibits checkpoint maintenance and homologous recombination repair by promoting the destabilization of the RPA–ssDNA complex, thereby sensing cancer cell lines with high SLFN11 to DDAs [96]. This evidence concerns the gene RPA1 and cancer.