In conclusion, we found that though the low ALT cutoff values (30 U/L for men, 19 U/L for women) do predict the risks of liver-related mortality, HCC, and decompensated liver events, the optimal ALT values for the average risk person in South Korea closely track with the new AASLD recommendations of an ALT of 35 for men and 25 for women. The gene discussed is GPT; the disease is hepatocellular carcinoma.