By both low ALT cut-off (≤30 U/L in men and ≤19 U/L in women) and conventional ALT cut-off (ALT ≤ 40 U/L for both men and women), subjects with higher ALT levels had significantly higher liver-related mortality, incidence of HCC, and decompensated liver events (p < 0.0001 for both cut-offs in all three endpoints) (Figure 3, Supplementary Tables S1 and S2). This evidence concerns the gene GPT and hepatocellular carcinoma.