Another study revealed that the appearance of adipocytes and muscle loss observed in limb-girdle muscular dystrophy 2B (LGMD2B) is caused by the accumulation of Annexin A2 (AnxA2) in FAP cells, and that pharmacological inhibition of adipogenesis can ameliorate muscle pathology caused by dysferlin deficiency [134]. This evidence concerns the gene ANXA2 and autosomal recessive limb-girdle muscular dystrophy type 2B.