Another study revealed that the appearance of adipocytes and muscle loss observed in limb-girdle muscular dystrophy 2B (LGMD2B) is caused by the accumulation of Annexin A2 (AnxA2) in FAP cells, and that pharmacological inhibition of adipogenesis can ameliorate muscle pathology caused by dysferlin deficiency [134]. Here, DYSF is linked to hyperinsulinemic hypoglycemia, familial, 4.