Thus, low p27CA concentration in plasma may mean a positive effect of rHuIFN-α treatment, similarly to what happens in HIV patients, in which the decrease of circulating p24CA levels induced by IFN-α correlates with the increase of CD4+ T-cells and an antitumoral response against Kaposi’s sarcoma [29]. This evidence concerns the gene IFNA2 and Kaposi's sarcoma.