CDKN1A and cancer: Mutations and rearrangements of the histone-lysine N-methyltransferase 2 (MLL) family proteins play a major role in the initiation and maintenance of various cancer types [20]; p53 might be involved in the correct recruitment of the Set1 complex to DNA-damage-responsive genes and thus links this phenotype to p21cip1/waf1 [21].