The long noncoding RNA plasmacytoma variant translocation 1 (PVT1) is upregulated in pancreatic duct adenocarcinoma (PDAC) tissues and has been shown to promote pancreatic cancer cell proliferation and migration, and epithelial-to-mesenchymal transition (EMT), by downregulating p21cip1/waf1 [120]. Here, PVT1 is linked to familial pancreatic carcinoma.