BOP1 and melanoma: Furthermore, more recently, Gupta et al. reported that the lack of block of proliferation 1 (BOP1) decreases the MAP phosphatases, dual specificity phosphatase (DUSP)4, and DUXP6, leading to increased MAP signaling and BRAF resistance in three human melanoma cell lines (SKMEL-239, SKMEL-28, A375) [29].