For instance, CD26, GM-CSF, SerpinE1, TIMP-1, HB-EGF, TSP-1, and GDNF were up-regulated and phospho-p53 (S15), phospho-p53 (S46), phospho-p53 (S392), pro-caspase-3, and cytochrome C were down-regulated in the tumor spheroids in co-culture. The gene discussed is TP53; the disease is neoplasm.