Another study conducted on NOD mice showed that short-term administration of a calcitriol analogue inhibits LPS-induced interleukin (IL)-12 and IFN-γ production, arrests Th1 cell infiltration within the pancreatic islets, enhances the frequency of CD4+CD25+ regulatory T cells within the pancreatic lymph nodes, curbs the progression of insulitis, and prevents development of diabetes at non-hypercalcemic doses [94]. This evidence concerns the gene CD4 and diabetes mellitus.