In addition, complete macroscopic and microscopic resection (R0) [3,29,30,32,40], liver-limited disease (with the exception of isolated pulmonary and bony metastases) [23,39,59], solitary BCLM [36,41], a long interval (more than 1 year) between breast cancer diagnosis and the detection of BCLM [21,28,29,35,37,57] and patients with PgR- and/or ER-positive BCLM [21,22,23,27,30,34,60] were independent prognostic factors. The gene discussed is PGR; the disease is breast cancer.