Under DS conditions, levels of CD8+CD103+ T cells increase and play an immunoregulatory role at the ocular surface and in CLNs; however, co-transfer of CD8+CD103+ Tregs does not suppress Th17 pathogenic response at the ocular surface, indicating that these Tregs suppress the production of pathogenic Th17 cells before their initiation by suppressing DC activation [31]. The gene discussed is CD8A; the disease is Dravet syndrome.