KLRK1 and neuroblastoma: Another promising approach was developed in neuroblastoma patients infused with high doses of IL-2-activated allogeneic NK cells displaying elevated NKG2D levels; results from this trial showed that the treatment reduced sMICA plasma levels and improved NK-cell cytotoxicity, indicating that NKG2D overexpression can quantitatively scavenge soluble ligands and preserve cytotoxicity of NK cells via non-occupied NKG2D [119] (Figure 1).