Our meta-analysis of TNF, TNFR1 and TNFR2 mRNA expression in RNA-seq datasets in the SRA extended a previous study of TNF [13,14], indicating its implication in the immune response by showing that mRNAs of both TNF and TNFR1 are induced in spleen and in immune cells upon virus infection and LPS treatment. Here, TNFRSF1B is linked to viral infectious disease.