In short, our results suggest that very long-chain n-3 PUFAs, by protecting goblet cells against ER stress-mediated altered Muc2 secretion induced by PAL, could be potential therapeutic nutrients used in strategies against the detrimental lipotoxicity of saturated FA, associated with type 2 diabetes and obesity or inflammatory bowel disease. The gene discussed is MUC2; the disease is obesity due to melanocortin 4 receptor deficiency.