MUC2 and serum lipopolysaccharide activity: The mucus layer, mainly comprised of the glycoprotein Muc2 produced by intestinal goblet cells [45], forming a physical barrier protecting the underlying epithelium against luminal substances and microbes [46,47], has been shown to be considerably altered under diets rich in saturated FA [11,18], exacerbating epithelium leakage and endotoxemia.