Considering the substantial evidence that multiple genes and proteins (amyloid β-protein (Aβ)40, Aβ42 [93], choline acetyl-transferase [94], protein kinase C [95], adrenocorticotropic hormone, corticotropin releasing hormone [96]) expressions could be modulated by catalpol in protection against AD, these may also become new potential targets in the management of DE. The gene discussed is CRH; the disease is Alzheimer disease.