EMT of melanoma cells is under regulation of transcription factors (Zeb, Snail, Twist) that in turn are affected by several signaling pathways, like the RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, Wnt/ß-catenin, or TGF-ß pathways [20]. The gene discussed is MAP2K7; the disease is melanoma.