Due to the lack of data, exploring the mechanisms of SSZ during HIV-1 infection, particularly those related to inflammasomes, the results of our study had to be compared with those reported for other immunomodulatory molecules that have been used in people living with HIV; e.g., both statins, which inhibit the activation of T cells and monocytes (a main source of IL-1β) [34,35], and chloroquine, a lysosomotropic drug [36], alter the signaling pathway of intracellular TLRs and NF- κB, thereby suppressing the inflammatory environment, which is the hallmark of HIV infection. Here, IL1B is linked to HIV-1 infection.