Recently, using molecular dynamics simulation, we demonstrated that MICA-TM, one of the candidate peptides that induced proliferation of PBL from patients with BD, had a significantly stronger total binding free energy with the BD-associated HLA alleles (HLA-B*51:01 and A*26:01) than with the non-associated alleles (HLA-B*35:01 and A*11:01) [21]. The gene discussed is HLA-B; the disease is Behcet disease.