FG-3019-treated mice achieved 61.7%, 53.5%, and 56.7% reduction of immune cell infiltration, stromal reaction, and ADM, respectively, compared with the FG-hulgG-treated group (Fig 7E), suggesting that neutralization of CTGF partially rescued the pancreatitis induced by Lats1/2 deletions in adult acinar cells. This evidence concerns the gene LATS1 and pancreatitis.