IκB is an inhibitor of the transcription factor NF‐κB, which is a mediator of the growth responses induced by a variety of pro‐hypertrophic agonists.56 NF‐κB is recognized as a key transcription factor mediating cardiac hypertrophy.57 The inhibitor of IκB kinase (IKK) complex (IKKα, IKKβ and IKKγ) contributes to the phosphorylation of IκB under stimulation.58, 59 AKAP‐Lbc promotes the activation of anchored IKKβ, which in turn results in the phosphorylation and degradation of IκB and activation of NF‐κB. This evidence concerns the gene NFKB1 and cardiac hypertrophy.