AKAP150 anchors CaN and mediates nuclear factor of activated T cell c3 (NFATc3) activation and the transcriptional suppression of regulatory BK‐β1 subunit during diabetes induced by glucose,29 and the BK‐β1 subunit is a crucial regulatory factor of vascular tone.71 In conclusion, anchoring of calcineurin by AKAP150 is required for BK channel impairment during hyperglycaemia and diabetes, which promotes enhanced vascular tone.29 This evidence concerns the gene NUP214 and diabetes mellitus.