Type 1 long QT syndrome (LQT1) results from the disruption of this complex.85 Further experiments were performed to explore the Yotiao missense mutational site, and S1570‐Yotiao was shown to modify Yotiao/KCNQ1 interactions and PKA phosphorylation; furthermore, it also reduced the functional response of Iks channels to cAMP. The gene discussed is KCNQ1; the disease is long QT syndrome 1.