KCNMA1 and diabetes mellitus: AKAP150 anchors CaN and mediates nuclear factor of activated T cell c3 (NFATc3) activation and the transcriptional suppression of regulatory BK‐β1 subunit during diabetes induced by glucose,29 and the BK‐β1 subunit is a crucial regulatory factor of vascular tone.71 In conclusion, anchoring of calcineurin by AKAP150 is required for BK channel impairment during hyperglycaemia and diabetes, which promotes enhanced vascular tone.29