IL6 and rheumatoid arthritis: In the process of AAA, NF‐κB signalling has multifunctional effects on mediating the expression of pro‐inflammatory cytokines.32, 33, 34 NONO increased IL‐1β as well as IL‐6 production in RAW 264.7 cells with TNF‐α stimulation via NF‐κB pathways, triggering inflammation.10 Other studies also showed that NONO prompts inflammation through NF‐κB in rheumatoid arthritis progression.14 As a multifunctional nuclear factor, NONO affected almost every step of gene regulation and many protein expression levels.