The risk factors of AAA include smoking, age, male gender, levels of lipid profiles and high blood pressure.20, 21, 22, 23, 24 Joint effects of multiple factors may be necessary in growth and stabilization of functional vessels, such atherosclerosis and AAA tissues.25, 26, 27, 28 Knockdown of NONO showed no influence in lipid profile and BP in Ang II‐induced AAA in ApoE−/− mice, suggesting that the effect of NONO on AAA was independent of them. The gene discussed is AGT; the disease is hypertensive disorder.