SOD1 and Hepatic fibrosis: Besides, the expression of PPAR-γ, Nrf2, HO-1, and SOD was increased, while TGF-β1/Smad, Wnt/β catenin, and MAPK signaling pathways could be suppressed by dioscin to mitigate oxidative stress and alleviate hepatic fibrosis [108, 111], suggesting that dioscin could be a promising candidate with multiple targets in liver fibrosis.