Compared with those of group M, high dose of RSG could significantly reduce serum Cr and Ur levels in HUA rats, but serum AST, ALT, and T-BIL levels in this group were significantly increased; combined with this, microscopic pathological examination showed liver damage, which suggests high dose of RSG could alleviate the degree of kidney damage in rats but might cause certain liver damage. Here, GPT is linked to Nephropathy.