As illustrated by the representative blots and densitometry analysis of five independent experiments shown in Fig. 7a, EBV infection was associated with progressive increase of both EBNA1 and MTH1 expression, starting between day 3 and 6 when the peak of ROS begins to subside [14] and culminating after ~2 weeks when immortalized lymphoblastoid cell lines became established. This evidence concerns the gene NUDT1 and Epstein-Barr virus infection.