ITGAL and neoplasm: As expected from our in vitro data, metastatic area and recruitment of LSECs and HSCs to the tumor foci was lower in C26 cell metastasized livers collected from ICAM-1 siRNA treated mice or from C26 cells pretreated with CD11a antibodies, in line with our groups previous studies disrupting the LSEC ICAM-1/C26 cell LFA-1 crosstalk through β2 integrin blocking16.