They also exhibit IL-22-expressing CD4/CD8 T cells in their cutaneous lesions, show imbalanced circulating Th22 cells, and display Tc22 cell induction after staphylococcal enterotoxin stimulation, with enhanced expression of IL4 and IL22 in AD skin11; altogether emphasizing their Th2/T22-biased response11. This evidence concerns the gene IL4 and Alzheimer disease.